Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 8, Pages 1129-1131Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc16480a
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Funding
- Whitelaw Frater Cancer Trust
- Big C Cancer Appeal
- EPSRC
- EPSRC [EP/H031855/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H031855/1] Funding Source: researchfish
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Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.
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