4.7 Article

Palladium-catalyzed direct arylation of benzoxazoles with unactivated simple arenes

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 71, Pages 8964-8966

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34238c

Keywords

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Funding

  1. 973 Program [2011CB932404, 2011CBA00501]
  2. NSFC [20821061, 20925102]
  3. CAS of Fujian Province
  4. NSF of Fujian Province [2009HZ0005]

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Using CuBr2 as an additive, the Pd-catalyzed intermolecular C-H-C-H cross-coupling between benzoxazoles and unactivated simple arenes has been developed. This protocol provides a straightforward approach for the biological activity of 2-arylbenzoxazole derivatives.

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