4.7 Article

Chemoenzymatic preparation of germacrene analogues

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 78, Pages 9702-9704

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35542f

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Funding

  1. United Kingdom's Biotechnology and Biological Sciences Research Council [BB/G003572/1, BB/H01683X/1]
  2. Cardiff University
  3. Biotechnology and Biological Sciences Research Council [BB/H01683X/1, BB/G003572/1] Funding Source: researchfish
  4. BBSRC [BB/G003572/1, BB/H01683X/1] Funding Source: UKRI

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A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

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