Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 90, Pages 11079-11081Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35738k
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Funding
- National Natural Science Foundation of China [81172916]
- Ministry of Science and Technology of China [2012CB822100]
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An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting aldehyde tag'' was presented. A variety of functional groups could be introduced into the protein of interest.
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