Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 67, Pages 8347-8349Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32919k
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Funding
- National Basic Research Program of China [2010CB732402]
- NSFC [21075104]
- NSF of Fujian Province for Distinguished Young Scholars [2010 J06004]
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In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruplex based DNAzymes.
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