Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 29, Pages 3485-3487Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc18077d
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Funding
- National Natural Science Foundation of China [20872042, 201032001]
- PCSIRT [IRT0953]
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A highly efficient method for the synthesis of oxazole derivatives from methyl ketones, benzoins and ammonium acetate has been established via a novel strategy-convergent integration of two self-labor domino sequences. Owing to the simple and readily available starting materials, mild reaction conditions, facile operation, and the high bioactivity of oxazole derivatives, this reaction promises diverse applications in medical chemistry. Additionally, this reaction could provide an efficient example for self-labor synthesis strategy of organic compounds.
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