4.7 Article

Sensitive SERS detection of DNA and lysozyme based on polymerase assisted cross strand-displacement amplification

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 88, Pages 10892-10894

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35688k

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Funding

  1. National Natural Science Foundation of China [21025523, 21275086]
  2. National Basic Research Program of China [2010CB732404]
  3. Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)

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A novel surface-enhanced Raman scattering (SERS) assay is demonstrated by developing a cross strand-displacement amplification (CSDA) method to enhance the SERS signals. Highly sensitive and selective detection of any single-stranded DNA is achieved and an aptasensor for proteins is constructed.

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