4.7 Article

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 38, Pages 4570-4572

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31230a

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Funding

  1. Grants-in-Aid for Scientific Research [12J07172] Funding Source: KAKEN

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The direct aldol reaction of an alpha-alkyl-alpha-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a gamma-oxo-beta-hydroxy-alpha-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

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