Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 96, Pages 11766-11768Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36785h
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Funding
- NSF of China [21136002, 2107603, 20923006]
- National Basic Research Program of China [2009CB724706, 2013CB733702]
- Scientific Research Fund of Liaoning Provincial Education Department [LS2010040]
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Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol. Rlyso was successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the alkalizing effect on lysosomes of current lysosomal probes with nitrogen-containing sidechains.
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