Journal
JOURNAL OF GENETICS AND GENOMICS
Volume 42, Issue 10, Pages 563-577Publisher
SCIENCE PRESS
DOI: 10.1016/j.jgg.2015.07.003
Keywords
MicroRNA; Signaling pathway; Tumorigenesis; Pancreatic ductal adenocarcinoma
Funding
- Tianjin Medical University General Hospital
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Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.
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