4.7 Article

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 42, Pages 5160-5162

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30931a

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Funding

  1. National Science Foundation of China [21072069, 21002036]
  2. National Basic Research Program of China [2011CB808603]

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An efficient organocatalytic Michael-aldol cascade reaction for the asymmetric synthesis of spirocyclic oxindole derivatives fused with tetrahydrothiophenes has been developed through a formal [3 + 2] annulation strategy.

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