4.7 Article

Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 65, Pages 8138-8140

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33600f

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Funding

  1. National Natural Sciences Foundation of China [20975101]
  2. Creative Research Group Project by NSFC [21021004]
  3. China State Key Basic Research Program Grant [2012CB910101]
  4. Analytical Method Innovation Program of MOST [2009IM031800, 2010IM030500]

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Hybrid Fe3O4@SiO2@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with high specifity, high sensitivity, and large binding capacity.

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