Journal
JOURNAL OF GENETICS AND GENOMICS
Volume 42, Issue 5, Pages 261-274Publisher
SCIENCE PRESS
DOI: 10.1016/j.jgg.2015.04.006
Keywords
CTP synthase; Cytoophidium; Drosophila; Central nervous system; Neuroepithelial stem cell
Funding
- UK Medical Research Council
- MRC [MC_UU_12021/3, MC_U137788471] Funding Source: UKRI
- Medical Research Council [MC_UU_12021/3, MC_U137788471] Funding Source: researchfish
Ask authors/readers for more resources
CTP synthase (CTPsyn) is a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTP. Several recent studies have shown that CTPsyn forms filamentous subcellular structures known as cytoophidia in bacteria, yeast, fruit flies and humans. However, it remains elusive whether and how CTPsyn and cytoophidia play a role during development. Here, we show that cytoophidia are abundant in the neuroepithelial stem cells in Drosophila optic lobes. Optic lobes are underdeveloped in CTPsyn mutants as well as in CTPsyn RNAi. Moreover, overexpressing CTPsyn impairs the development of optic lobes, specifically by blocking the transition from neuroepithelium to neuroblast. Taken together, our results indicate that CTPsyn is critical for optic lobe homeostasis in Drosophila.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available