4.7 Article

Construction of α-amido-indanones via formal allenamide hydroacylation-Nazarov cyclization

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 73, Pages 9186-9188

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34644c

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Funding

  1. NSERC
  2. Alberta Innovates-Technology Futures
  3. University of Alberta

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A two-step modular synthesis of an alpha-hydroxycyclopentenone and alpha-amido-indanones has been developed based on the Nazarov cyclization of 2-amido-1,4-pentadien-3-ones, readily accessed via formal hydroacylation of allenamides.

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