Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 81, Pages 10126-10128Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34768g
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Funding
- National Natural Science Foundation of China [50873089, 21074110]
- Science and Technology Plan of Zhejiang Province [2010C31025]
- Fundamental Research Funds for the Central Universities [2011QNA4025]
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PEG-detachable polyplexes were constructed for the first time via host-guest interactions between beta-cyclodextrin and azobenzene. The polyplexes had excellent colloidal stability and competition stability. Moreover, the intracellular light-regulated dePEGylation facilitated DNA release and nuclear entry, thus resulting in efficient transfection.
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