Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 90, Pages 11097-11099Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35872g
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23657084, 22121511] Funding Source: KAKEN
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Simple substitution of D-lysine with D-arginine in antimicrobial peptide (RLA) considerably improved its membrane permeability and increased mitochondrial accumulation. The potential use of RLA in preventing apoptotic cell death is also demonstrated through delivery of the Bcl-x(L) BH4 domain peptide.
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