4.7 Article

An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 90, Pages 11133-11135

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36340b

Keywords

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Funding

  1. National Basic Research Program of China [2012CB720602, 2011CB936004]
  2. National Natural Science Foundation of China [20831003, 90813001, 20833006, 90913007, 21072182]

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Based on selective pore-opening in the presence of protease, we have developed a novel signal amplification assay for multiple proteases detection and their inhibition using protein-capped mesoporous scaffolding as the substrate.

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