4.7 Article

Enantioselective alkylation of beta-keto phosphonates by direct use of diaryl methanols as electrophiles

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 76, Pages 9528-9530

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35262a

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Funding

  1. Funding Program for Next Generation World-Leading Researchers [GR025]
  2. MEXT, Japan

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Enantioselective alkylation of beta-keto phosphonates with diaryl methanols in the presence of catalytic amounts of copper(II) trifluoromethanesulfonate and an optically active ligand gives the corresponding alkylated products in good to high yields with a high enantioselectivity.

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