4.7 Article

Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 74, Pages 9257-9259

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34935c

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Funding

  1. NIH [R01CA142746]
  2. HFSP
  3. Brandeis University
  4. NATIONAL CANCER INSTITUTE [R01CA142746] Funding Source: NIH RePORTER

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As the first example of hydrogelator derived from aminoglycoside antibiotics, the hydrogel of kanamycin indicates that the hydrogel of aminoglycosides preserve the specific interaction with their macromolecular targets (e. g., 16S rRNA), thus illustrating a simple approach to explore and identify possible biological targets of supramolecular nanofibers/hydrogels.

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