Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 59, Pages 7401-7403Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32292g
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Funding
- DGICYT [CTQ 2009-07758]
- Generalitat de Catalunya [2009/SGR/208]
- Barcelona Science Park
- A*STAR (Singapore) [10/1/21/19/656]
- Grupo Ferrer (Barcelona, Spain)
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Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.
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