4.7 Article

Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 92, Pages 11340-11342

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36130b

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Funding

  1. EPSRC
  2. Pfizer Institute for Pharmaceutical Materials Science
  3. EU
  4. Engineering and Physical Sciences Research Council [1127438] Funding Source: researchfish

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The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

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