Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 40, Pages 4845-4847Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30603d
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- global COE, High-Tech Research Center
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We report a mitochondrial targeted redox probe (MitoRP) that comprises a nitroxide radical (TEMPO) moiety and coumarin 343. Using isolated mitochondria in the presence/absence of substrates and inhibitors of oxidative phosphorylation, we demonstrated that MitoRP is a useful probe to monitor the electron flow associated with complex I.
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