Journal
JOURNAL OF NEUROTRAUMA
Volume 17, Issue 9, Pages 773-780Publisher
MARY ANN LIEBERT INC PUBL
DOI: 10.1089/neu.2000.17.773
Keywords
excitotoxicity; glucocorticoids; glutamate release; myelin; spinal cord trauma
Funding
- NINDS NIH HHS [R01 NS040015, NS40015, NS30248] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040015, R01NS030248] Funding Source: NIH RePORTER
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The potential use of riluzole (a glutamate release inhibitor) alone or in combination with methylprednisolone (MP) in treating acute spinal cored injury (SCI) was examined. Rats received a contusion injury to the spinal cord using the NYU impactor and were treated with vehicle, riluzole (8 mg/kg), MP(30 mg/kg), or riluzole + MP at 2 and 4 h following injury. Animals continued to receive riluzole treatment (8 mg/kg) for a period of 1 week. The animals were then tested weekly for functional recovery using the BBB open field locomotor score. At the end of testing (6 weeks after injury), each spinal cord was examined for the amount of remaining tissue at the injury site and a myelination index was used to quantify remaining axons in the ventromedial white matter. In this study, only the combination treatment was found to significantly improve behavioral recovery as assessed using the BBB open field locomotor scale. In addition, the combination treatment promoted tissue sparing at the lesion epicenter, but had no clear effect on the index of myelnation. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of traumatic SCI.
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