Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 70, Pages 8820-8822Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34531e
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Funding
- Natural Science Foundation of China [21025521, 21035001, 21190041]
- National Key Basic Research Program [2011CB911000]
- CSIRT Program
- NSF of Hunan Province [10JJ7002]
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Based on a target-activated autocatalytic DNAzyme amplification strategy, novel fluorescence sensing platforms were constructed for highly sensitive and selective assay of base excision repair enzyme activity. By using a rolling circle amplification (RCA)-coupled amplification cascade, an extremely low detection limit (0.002 U mL(-1)) was achieved.
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