4.7 Article

Nanogold-based bio-bar codes for label-free immunosensing of proteins coupling with an in situ DNA-based hybridization chain reaction

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 100, Pages 12207-12209

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36820j

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Funding

  1. 973'' National Basic Research Program of China [2010CB732403]
  2. National Science Foundation of Fujian Province [2011J06003]
  3. National Natural Science Foundation of China [21075019, 41176079]
  4. Research Fund for the Doctoral Program of Higher Education of China [20103514120003]

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A label-free, non-enzyme immunosensing strategy is designed for ultrasensitive electronic detection of disease-related proteins (carcinoembryonic antigen as a model) by using gold nanoparticle-based bio-bar codes and an in situ amplified DNA-based hybridization chain reaction.

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