Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 18, Pages 2424-2426Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17069h
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Funding
- National Basic Research Program of China (973 Program) [2011CB933600]
- National Natural Science Foundation of China [20975013]
- Program for New Century Excellent Talents in University [NCET-08-0046]
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Efficiently labeling nucleic acids of fully replicative viruses is a challenge. In this work, a 'molecular light switch' complex [Ru(phen)(2)(dppz)](2+), where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2',3'-c]phenazine, has been exploringly used to label vaccinia virus nucleic acid. The labeled virions exhibited strong and stable fluorescence and could be imaged at the single-virion level. Moreover, they were fully infectious and can be used to study the behaviors of invasion into their host cells. The method is general and suitable for labeling various DNA viruses.
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