Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 76, Pages 9462-9464Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32253f
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Funding
- Hong Kong Baptist University [FRG2/10-11/008, FRG2/11-12/009]
- Environment and Conservation Fund (ECF Project) [3/2010]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
- Research Fund for the Control of Infectious Diseases [RFCID/11101212]
- Research Grants Council [HKBU/201811]
- University of Macau [MYRG091(Y1-L2)-ICMS12-LCH, MYRG121(Y1-L3)-ICMS12-LCH]
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A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.
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