Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 2, Pages 308-310Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc16582h
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Funding
- MEXT, Japan
- Novartis Foundation (Japan)
- Osaka University
- JSPS
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Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.
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