4.7 Article

Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C-N chelate amido ligands

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 30, Pages 3635-3637

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30333g

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan [22225004]
  2. GCOE Program
  3. Grants-in-Aid for Scientific Research [22225004] Funding Source: KAKEN

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The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution.

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