4.7 Article

Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 30, Pages 3632-3634

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc18052a

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Funding

  1. Asahi Glass Foundation
  2. [21390030]
  3. [22106515]
  4. [23915014]
  5. [2105]
  6. Grants-in-Aid for Scientific Research [10J08891] Funding Source: KAKEN

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The first asymmetric synthesis of beta-trifluoromethylated pyrroline carboxylates has been achieved by organocatalytic conjugated addition of adamantyl glycine imine to beta-trifluoromethylated enones, followed by a deprotection/cyclization/dehydration sequence.

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