Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 31, Pages 3709-3711Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30295k
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- Northern Illinois University
- University of Oxford
- Yale University
- Universities of Leicester and Oxford
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A synthetic scaffold that mimics a peptide beta-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide beta-strand.
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