Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 69, Pages 8655-8657Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34841a
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The double addition of Grignard (alkyl, aryl, alkenyl, alkynyl) reagents to acyl cyanohydrins was performed under unusually smooth conditions with a concomitant O-N acyl transfer, providing a very simple and general access to alpha,alpha,alpha-trisubstituted amides.
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