Enhanced permeation of triamcinolone acetonide through the buccal mucosa

To develop new formulations that have suitable bioadhesive force and provide sustained release in buccal area for an extended period of time, bioadhesive gels containing triamcinolone acetonide were prepared using two polymers, carbopol 934 and poloxamer 407 which were selected for their bioadhesiveness and gelling property, respectively. The drug release profiles from the gels a ere studied as a function of drug concentration and temperature. Different enhancers such :ls bile salts, glycols and non-ionic surfactants were used for the enhancement of its permeation through buccal mucosa. Among the enhancers used, sodium deoxycholate showed the best enhancing effects. (C) 2000 Elsevier Science B.V. All rights reserved..