4.7 Article

pH-triggered blooming of 'nano-flowers' for tumor intracellular drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 65, Pages 8129-8131

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34225a

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Funding

  1. National Basic Research Program of China [2011CB606202, 2009CB930300]

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With the decrease in pH value, the 'nano-flower' exhibited a half-open state to expose the target ligands on the surface under tumor acidic conditions and fully bloomed to release Dox under endosomal acidic conditions.

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