Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 11, Pages 1692-1694Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17067a
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Funding
- 111 Project [B07023]
- East China University of Science Technology
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An enantioselective Michael addition of ketones to alkylidene-malononitriles catalyzed by chiral primary amine I with (R)-5c as a co-catalyst in good yields (> 90%) and with good enantioselectivities (85-96% ee) has been developed. The strategy has also been extended to a three-component version through a domino Knoevenagel/Michael sequence with similar or better outcomes.
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