Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 43, Pages 5322-5324Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17937g
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Funding
- CICYT [CTQ2009-07758, 2008-00177]
- ISC III [CB06_01_0074]
- Generalitat Catalunya [2009SGR 1024]
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Aniline-catalyzed oxime chemistry was employed to conjugate a gamma-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate.
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