Journal
GLYCOCONJUGATE JOURNAL
Volume 17, Issue 3-4, Pages 143-151Publisher
SPRINGER
DOI: 10.1023/A:1026524820177
Keywords
glycosphingolipid signaling domain (GSD); cell adhesion; detergent-insoluble material (DIM); signal transducer molecules; transcription factors; GM3; Gal-globoside
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Funding
- NCI NIH HHS [CA42505, CA80054] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA080054, R35CA042505] Funding Source: NIH RePORTER
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Glycosphingolipids (GSLs) and sphingomyelin in animal cells are clustered and organized as membrane microdomains closely associated with various signal transducer molecules such as cSrc, Src family kinases, small G-proteins (e.g., RhoA, Ras), and focal adhesion kinase. GSL clustering in such microdomains causes adhesion to complementary GSLs on the surface of counterpart cells or presented on plastic surfaces, through carbohydrate-to-carbohydrate interaction. GEL-dependent cell adhesion In microdomain causes activation of the signal transducers, leading to cell phenotypic changes. A retrospective of the development of this concept, and current status of our studies, are presented.
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