4.7 Article

A general intramolecular Friedel-Crafts approach to functionalized pyrrolo[3,2,1-ij]quinolin-4-ones

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 83, Pages 10337-10339

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34650h

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Funding

  1. National Science Foundation (CAREER Award) [CHE-1056687]
  2. Division Of Chemistry
  3. Direct For Mathematical & Physical Scien [1056687] Funding Source: National Science Foundation

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An indium(III)-catalyzed intramolecular Friedel-Crafts annulation for the efficient synthesis of pyrrolo[3,2,1-ij]quinolin-4-ones is described. The products are formed in good to excellent yields (51-97%) with diastereoselectivities up to >99 : 1 dr.

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