Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 76, Pages 9516-9518Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34399a
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Funding
- European Commission through the COST Action [MP0802]
- Italian MURST (PRIN)
- KU Leuven [PF 10/18, GOA 10/14]
- FWO
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This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC50 values against HIV-1 in the range of 0.04-0.15 mu M as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
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