Journal
MICROVASCULAR RESEARCH
Volume 59, Issue 2, Pages 290-300Publisher
ACADEMIC PRESS INC
DOI: 10.1006/mvre.1999.2215
Keywords
interstitial fluid flows; bone; biomechanics; histomorphometry
Categories
Ask authors/readers for more resources
Ferritin was used as a histological marker for interstitial fluid flows in four goats. Two transcortical pins were inserted into each tibia mediolaterally-one at the proximal side and one at the distal side of the diaphysis. For the experimental limb, dynamic loading was applied to the pins on the lateral side. The contralateral limb was used as control. Ferritin was injected into the nutrient arteries feeding the two tibiae. The goat was then euthanized immediately. Undecalcified slides of the tibial cortical bone from both the experimental and the control limbs were studied histologically. Percentages of Haversian systems marked with ferritin halos and the average radial distance of ferritin transudation away from the Haversian canals were assessed. Results for the medial and lateral sides of both the experimental and control tibiae were reported. Significant differences in the ferritin transudation distance were found between the experimental and the control tibia (P < 0.005) and between the medial and the lateral sectors (P < 0.05). The approach documented in this paper could be used to address systematically how external loading might affect the transport phenomena in cortical bone. (C) 2000 Academic Press.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available