Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 19, Pages 2522-2524Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc16087k
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Funding
- Gyeonggi Regional Research Center (GRRC)
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology [2011-0004766]
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We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.
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