Journal
JOURNAL OF VASCULAR RESEARCH
Volume 37, Issue 2, Pages 103-111Publisher
KARGER
DOI: 10.1159/000025721
Keywords
echo-tracking; pressor response; pressure-diameter relation; hysteresis
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In clinical studies, the elastic behavior of central arteries is usually assessed by measuring dynamic distensibility. In this study, we aimed to investigate how dynamic and static distensibility of the common carotid artery (D-dyn and D-stat, respectively) are related in 28 healthy volunteers of 20-71 years. The carotid diameter and its change with the pressure pulse were measured using an ultrasound echo-tracking device. Arterial blood pressure was measured by Finapres and carotid pressure was determined by applanation tonometry. D-dyn was determined at rest using the pressure pulse, while D-stat was determined during presser responses induced by handgrip or cold presser test. Data are given as mean +/- 1 SD. In younger subjects (<35 years), D-stat did not differ from D-dyn (7.0 +/- 3.4 vs. 6.5 +/- 2.1.10(-3).mm Hg-1, respectively), whereas in older subjects (>35 years), D-stat was significantly higher than D-dyn (3.8 +/- 1.4 vs. 2.1 +/- 0.9.10(-3).mm Hg-1, p<0.001). For all subjects, D-stat and D-dyn decreased with increasing age and mean arterial pressure (MAP). Using stepwise multiple regression analysis, the strongest predictor of D-stat proved to be MAP, while that of D-dyn was age. D-stat was found to be linearly related to the hysteresis loop area of the pressure-diameter relation (r = 0.94), i.e. to vessel wall viscosity. It is concluded that, with increasing age, static distensibility overestimates the distension capacity of large arteries. Copyright (C) 2000 S. Karger AG, Basel.
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