Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 60, Pages 7492-7494Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33808d
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Funding
- NSF CAREER program [CHE-1055569]
- Robert A. Welch Foundation [C-1680]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0947054, 1055569] Funding Source: National Science Foundation
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Rhodium metallopeptides catalyze proximity-driven modification of peptide and protein substrates with enzyme-like selectivity. In this communication, we demonstrate that designed metallopeptide catalysts can be inhibited in a sequence-specific manner, mimicking the inhibition and regulation of natural enzymes. We demonstrate sub-micromolar inhibition by a histidine-containing inhibitor peptide, taking advantage of cooperative supramolecular assembly and inorganic coordination.
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