4.7 Article

A chromenoquinoline-based fluorescent off-on thiol probe for bioimaging

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 21, Pages 2722-2724

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc16593g

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Funding

  1. IISER Pune
  2. DAE [2010/20/37C/6/BRNS/2480]
  3. CSIR

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A new chromenoquinoline-based fluorescent off-on thiol probe 2 is reported. In aqueous buffer solutions at physiological pH, the probe exhibited 223-fold enhancement in fluorescence intensity by a Michael addition of cysteine to the maleimide appended to a chromenoquinoline. Cell permeability and live cell imaging of thiols are also demonstrated.

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