Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 42, Pages 5076-5078Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31602a
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [23350017] Funding Source: KAKEN
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We report an asymmetric oxy-Michael addition to a gamma-hydroxya, alpha,beta-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organo-catalysts. This method provides a novel enantioselective route to beta-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.
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