Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 57, Pages 7215-7217Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33140c
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Funding
- National Science Foundation [0755053]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0755053] Funding Source: National Science Foundation
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Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.
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