4.7 Article

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 21, Pages 6006-6008

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11627d

Keywords

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Funding

  1. National Science Foundation of China [90713020, 20975103, 21020102039]
  2. Chinese Academy of Sciences
  3. Ministry of Science and Technology of China [2007CB935601]
  4. European Research Council [247450]
  5. ERDF/AWM/Science City
  6. EC

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Cisplatin, cis-[Pt(Cl-2(NH3)(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

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