4.7 Article

Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 26, Pages 7500-7502

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11253h

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Funding

  1. Ministry of Education, Science and Technology [2010-0019773]
  2. Ministry of Knowledge Economy [2010-10033674]
  3. National Research Foundation of Korea (NRF), Korea [2010-0024645]

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A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 mu M. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

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