4.7 Article

Artificial metalloenzymes for olefin metathesis based on the biotin-(strept)avidin technology

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 44, Pages 12065-12067

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15004a

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Funding

  1. SNF [FN 200020_126366]
  2. Marie Curie Training Network [238434]
  3. International Centre for Frontier Research in Chemistry (FRC), Strasbourg
  4. University of Basel

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Incorporation of a biotinylated Hoveyda-Grubbs catalyst within (strept) avidin affords artificial metalloenzymes for the ring-closing metathesis of N-tosyl diallylamine in aqueous solution. Optimization of the performance can be achieved either by chemical or genetic means.

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