Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 16, Pages 4649-4651Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05216g
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Funding
- EPSRC [EP/F005407/1]
- Royal Society
- Kate Dempsey of Renishaw Diagnostics Limited
- Engineering and Physical Sciences Research Council [EP/F005407/1] Funding Source: researchfish
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A novel DNA assay is demonstrated which relies on the production of a surface enhanced resonance Raman scattering (SERS) signal following sequence specific hybridisation and enzyme hydrolysis. This method achieves high sensitivity and specificity that can be applied to the detection of unlabelled duplex DNA and is the first step towards a SERS based signal amplification approach.
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